Our Phase I, II, & III, R&D effort,

focuses on:

Platform Architecture

The Bio Nexa platform combines multiple technical layers to create a modular, reusable, chiplet-based biosensing and biosurveillance architecture designed for scalable deployment across healthcare, research, and national biodefense systems.

Semiconductor Sensing Layer (“Wet” Biosensing Layer)

CMOS-compatible MEMS device architectures form the biological sensing interface, enabling continuous detection of low-concentration biochemical signals through electrically measurable interactions at functionalized sensor surfaces.

This “wet” biosensing layer supports real-time detection of critical biomarkers, including cytokines, hormones, and sepsis indicators, while remaining compatible with standard semiconductor fabrication environments.

Chiplet-Based Semiconductor Layer (“Dry” Electronics Layer)

The platform incorporates a modular, reusable, and interoperable chiplet-based architecture that separates sensing from computation and communication functions.

This “dry” chiplet layer includes:

• Power Chiplets: Ultra-low power management and energy optimization for continuous operation
• Processing Chiplets: On-chip signal conditioning, edge analytics, and data interpretation
• Secure Communication Chiplets: Encrypted transmission of sensitive biomedical data

This architecture enables scalable system integration, component reuse, and rapid reconfiguration across diverse biosensing applications.

Biocompatible Encapsulation & Selective Exposure Layer

A biocompatible encapsulation system provides hermetic sealing of semiconductor electronics while enabling controlled biological interaction at the sensing interface.

This layer supports:

• Long-term wearability
• Selective exposure membranes for fluid interaction
• Protection of sensitive electronic components

This is critical for reliable operation in clinical, field, and biodefense environments.

Signal Processing and Edge Intelligence

Advanced signal processing frameworks transform raw biochemical signals into interpretable data streams in real time.

Integrated artificial intelligence and machine learning models support:

• Signal classification
• Anomaly detection
• Adaptive interpretation of dynamic biological signals

These capabilities enable intelligent sensing systems operating in complex real-world environments.

Secure Data Infrastructure

The platform incorporates secure, encrypted data architectures designed to support protected biomedical data environments.

This enables:

• Trusted data transmission
• Integration with clinical and public health systems
• Secure biosurveillance across distributed networks

Modular Platform Design

The Bio Nexa platform is designed as a modular, chiplet-enabled system architecture supporting multiple sensing modalities and deployment environments.

This enables integration across:

• Wearable and minimally invasive devices
• Clinical and research instrumentation
• Distributed monitoring and biosurveillance systems

CMOS-Compatible Semiconductor Manufacturing

A core design principle of the platform is compatibility with existing semiconductor fabrication processes.

By leveraging mature CMOS manufacturing environments, the platform:

• Reduces technical risk
• Enables scalable production
• Supports domestic semiconductor fabrication under U.S. infrastructure initiatives

Applications

The platform supports a range of mission-critical applications, including:

• Continuous biosurveillance and biochemical monitoring systems
• Early detection of sepsis and infectious disease biomarkers
• Decentralized and remote clinical trial infrastructure
• Public health and population-level monitoring networks
• Environmental and biological threat detection systems
• Secure healthcare and biomedical data analytics platforms

Supporting the Domestic Semiconductor Ecosystem

By designing biosensing technologies compatible with existing semiconductor manufacturing environments, Bio Nexa supports the expansion of domestic semiconductor capabilities while enabling new application domains in healthcare and national security.

Research and Development Focus

Bio Nexa’s research efforts focus on advancing:

• CMOS-compatible biosensing device architectures
• Chiplet-based semiconductor integration
• Wet/dry system integration for biosensing platforms
• Biocompatible encapsulation and packaging technologies
• AI-enabled signal processing frameworks
• Secure biomedical data infrastructures
• Scalable biosurveillance systems for distributed environments
• Semiconductor manufacturing capacity and workforce development

Through this work, Bio Nexa demonstrates how modular, chiplet-based semiconductor systems can enable next-generation biosensing platforms, supporting resilient health infrastructure, real-time biosurveillance, and national biodefense readiness.